Tadalafil: A new oral therapy for erectile dysfunction
The oral inhibitors of phosphodiesterase type 5 (PDE5) appear to be the treatment of choice for the management of erectile dysfunction (ED). The combination of a high degree of efficacy (regardless of...
View ArticleTadalafil: A new oral therapy for erectile dysfunction – PHARMACOLOGY OF...
Sildenafil, vardenafil and tadalafil all work by targeting PDE5, but have distinct chemical structures and pharmacological properties. The time to maximum serum concentration for tadalafil, after oral...
View ArticleTadalafil: A new oral therapy for erectile dysfunction – OUTCOME MEASURES
Many trials of new drugs for ED use standardized, validated questionnaires as the major outcome measures. The most commonly used is the International Index of Erectile Function (IIEF), a questionnaire...
View ArticleTadalafil: A new oral therapy for erectile dysfunction – EFFICACY (Part 1)
Integrated analysis The most important data supporting the efficacy of tadalafil for ED come from an integrated analysis of five randomized, doubleblind, placebo-controlled, multicentre trials, four of...
View ArticleTadalafil: A new oral therapy for erectile dysfunction – EFFICACY (Part 2)
At all doses, tadalafil gave statistically significant improvements from baseline in erectile function compared with placebo. Figure 1 shows responses to SEP question 3, “Did your erection last long...
View ArticleTadalafil: A new oral therapy for erectile dysfunction – EFFICACY (Part 3)
Efficacy in men with diabetes The integrated analysis included men with diabetes, who made up 21% of the study population. Results showed significant improvements from baseline in all outcome measures...
View ArticleTadalafil: A new oral therapy for erectile dysfunction – EFFICACY (Part 4)
Period of responsiveness The period of effectiveness of tadalafil was assessed in a trial of 348 men with various severities of ED. Men in this doubleblind, placebo-controlled trial were instructed to...
View ArticleTadalafil: A new oral therapy for erectile dysfunction – PATIENT PREFERENCE
Ultimately, once all three PDE5 inhibitors are approved for use in Canada, patient preference as characterized by efficacy, safety, cost, ease of use and as-yet-unknown factors will determine the ED...
View ArticleTadalafil: A new oral therapy for erectile dysfunction – SAFETY (Part 1)
In all studies published to date, tadalafil has been generally well tolerated, with side effects comparable to those seen with other PDE5 inhibitors. The most common side effects have been dyspepsia...
View ArticleEnjoy Your Fantastic Sex Life with Cialis Professional!
Cialis Professional is a world’s known erectile dysfunction medication. It is reliable, efficient, safe and easy to use. The active ingredient of Cialis is Tadalafil. It helps improve erection and...
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